Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10–15%. However, this effect was only evident in post-chemotherapy consolidation after bulky primary tumors had largely been eliminated. Why retinoic acid is effective in this setting but not against primary tumors, has been speculated about for nearly 50 years.
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