Acute and chronic stress have markedly different impacts on neural repair in a depression-linked brain region

Researchers at Zhejiang University found that acute stress increases natural repair mechanisms in the brain, while chronic stress suppresses them. Autophagy was most affected in the lateral habenula, a brain region linked to emotional regulation. Several antidepressant drugs were tested and found to reverse this suppression, pointing to autophagy in the lateral habenula as a common therapeutic pathway in these treatments.