Gene signature of hepatic ferroptosis reveals its pathogenic features
By establishing an iron overload-induced hepatic ferroptosis model, scientists from Japan have identified iFerroptosis—an integrated gene signature for ferroptosis. They evaluated the associated genes in both mice and human liver injury systems, validating the potential use of iFerroptosis as a biomarker. By highlighting the role of ferroptosis in liver injuries, this study offers insights into unique therapeutic targets.
An AI-based classification system for facial pigmented lesions
A research team has developed a diagnostic system that uses artificial intelligence (AI) to accurately identify the type of facial pigmented lesions and support laser treatment decisions. A paper on this study was published online in Cureus.
Engineers create first immunocompetent leukemia device for CAR T immunotherapy screening
A team of researchers led by NYU Tandon School of Engineering’s Weiqiang Chen has developed a miniature device that could transform how blood cancer treatments are tested and tailored for patients.
Improvements to patient recovery strategies lower long-term opioid usage after colorectal surgery
Minimizing opioid exposure during and after colorectal surgery can decrease long-term opioid use in some patients, according to new research by Mass General Brigham investigators.
Proteins important in brain communication have different roles than previously thought
Cellular communication between neurons within our brain is complex and busy, much like a USPS mailroom.
Hidden bias may leave women and older adults underdiagnosed for HIV in Spain
A recent study analyzes the extent to which HIV tests are conducted following the diagnosis of an HIV indicator condition (IC) in primary care, as recommended by the World Health Organization and the European Centre for Disease Prevention and Control. The article “Implicit bias in HIV testing based on indicator conditions in primary care: a population-based study in Catalonia, Spain, 2017 to 2021” was published in Eurosurveillance and led by researchers from the IGTP’s research group Centre for Epidemiological Studies on HIV/AIDS and STI of Catalonia (CEEISCAT) and IDIAPJGol.
PHOx: An innovative, safer polymer for implantable medical devices
A scientific team from the University of Liège has just developed an innovative polymer, PHOx, which could significantly improve the safety of implantable medical devices, while being more environmentally friendly. This invention is the subject of an international patent application.
Understanding the role of pigmentation in hereditary hearing loss
Melanin can either protect or worsen hereditary hearing loss depending on genetic context, as reported by researchers from Japan. Using genetically engineered mice lacking the SLC26A4 gene, the researchers found that problems with melanin degradation led to its pathological accumulation in the inner ear, causing chronic inflammation and macrophage activation. These findings could inform new therapeutic strategies to minimize some forms of hereditary hearing loss.
Australian life expectancy inequality narrows, but disadvantaged areas still lag behind
Australia has made progress in reducing socioeconomic inequalities in life expectancy since the late 2010s, according to new research from The Australian National University (ANU), setting the country apart from many other high-income countries.
Multiscale simulations successfully connect micro- and macro levels of brain activity
Predicting how molecular changes affect the brain’s overall activity is a major challenge in neuroscience. Many deep questions about the brain can only be understood by looking at several layers of brain activity at the same time—with a so-called “multi-scale” approach. For a long time, this had been considered out of reach.