July 7, 2025
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Integrative exome sequencing and machine learning identify new genes contributing to systemic sclerosis risk

MyBlueDots01 mins
Systemic sclerosis (SSc) is a severe autoimmune disease with complex genetic causes. Some genetic contributors have been identified, but others remain unknown, which has impeded development of targeted treatments. In a new study published in Annals of the Rheumatic Diseases, researchers at Baylor College of Medicine and collaborating institutions used complementary approaches that integrate exome sequencing and evolutionary action machine learning to identify protein changes and their associated mechanisms in SSc.
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Early mitochondrial impairment and myelin loss tied to multiple sclerosis brain damage

MyBlueDots01 mins
Multiple sclerosis (MS) affects an estimated 2.3 million people worldwide. Approximately 80% of people with MS have inflammation in the cerebellum, the part of the brain that helps control movement and balance, potentially leading to tremors, poor coordination, and trouble with motor control. These problems often persist and can worsen over time, as the cerebellum gradually loses healthy brain tissue.
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Glial replacement therapy slows Huntington’s disease in adult mice

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Huntington’s disease has long defied attempts to rescue suffering neurons. A new study in Cell Reports shows that transplanting healthy human glial progenitor cells into the brains of adult animal models of the disease not only slowed motor and cognitive decline but also extended lifespan. These findings shift our understanding of Huntington’s pathology and open a potential path to cell-based therapies in adults already showing symptoms.
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Dad’s mental health linked to kid’s well-being

MyBlueDots01 mins
Dads with poor mental health may be impacting the development of their kids, with Australian research linking mental distress in fathers to poorer social-emotional, cognitive, language, and physical development in their kids. The review, which pooled together the results from 84 studies across 48 groups of people, found that these impacts were generally stronger for mental distress after birth than before birth, suggesting that a father’s mental state may exert a more direct influence on the developing child after birth.
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What’s really in our food? A global look at food composition databases

MyBlueDots01 mins
In today’s world, we hear a lot about what we should eat: more vegetables, less sugar and salt, and to obtain locally sourced, sustainable, and nutrient-rich food. But there’s a fundamental question most people don’t think about: How do we actually know what is in our food? The answer lies in food composition databases (FCDBs), which are collections of data about the nutritional content of different foods, from macronutrients like protein and fat, to vitamins, minerals and specialized biomolecules like antioxidants and phytochemicals.
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Immune tolerance to gut microbes is initiated by a key bacterial sensor, researchers discover

MyBlueDots01 mins
Thousands of bacterial and other microbial species live in the human gut, supporting healthy digestion, immunity, metabolism and other functions. Precisely how these microbes are protected from immune attack has been unclear, but now a study led by Weill Cornell Medicine investigators has found that this immune “tolerance” to gut microbes depends on an ancient bacterial-sensing protein called STING—normally considered a trigger for inflammation. The surprising result could lead to new treatments for inflammatory bowel disease and other conditions involving gut inflammation.
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