New approach reverses opioid overdoses more safely, rat study shows

Opioid overdoses are a major public health issue in the U.S., killing tens of thousands of people every year. The medicine naloxone, which is available as an over-the-counter nasal spray or given by injection, has saved countless lives by rapidly reversing opioid overdoses. But in blocking opioid receptors in the brain, naloxone causes severe withdrawal symptoms, including pain, vomiting and agitation.
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Organoids containing blood vessels have been grown, holding promise for research and treatment

For over a decade, scientists have been growing organoids—small clusters of cells that mimic a particular organ—to serve as miniature biological models. Organoids of the brain have been used to study neurodevelopmental disorders; intestinal organoids, to model celiac disease; and lung organoids, to investigate SARS-CoV-2. Heart organoids have even been sent to space to test the effect of microgravity on cardiac muscle. But there’s a tiny problem—the organoids can’t grow any bigger than a sesame seed.
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ASCO: Durvalumab plus FLOT beneficial for resectable gastric, GE junction cancer

For patients with resectable gastric or gastroesophageal junction adenocarcinoma, durvalumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) yields better event-free survival outcomes than FLOT alone, according to a study published online June 1 in the New England Journal of Medicine. The research was published to coincide with the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.
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Learning about autism from those who live on the spectrum through online forums

A group of researchers from the Department of Psychology and Cognitive Science of the University of Trento, together with colleagues from US and British universities and departments, delved into the world of people with autism through their conversations, learning about their interests, the topics they discuss, their needs, tastes, experiences. They worked from the ground up, examining discussions and narratives to shed light on things that usually remain unknown to outsiders.
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