Molecule reverses cognitive deficits associated with aging and dementia in animal tests

In Brazil, researchers from the Federal University of Rio de Janeiro (UFRJ) and collaborators from the University of São Paulo (USP) have discovered that a molecule called Hevin can reverse cognitive impairment. The study, conducted in mice, showed that this glycoprotein produced by brain cells (astrocytes) is able to increase the connections between neurons (synapses) in aged rodents and in animal models of Alzheimer’s disease.
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Wireless device enables precise activation of light-sensitive pain drugs in animal study

Photoactivable drugs are activated when irradiated by a beam of light—via an optical fiber—thus generating a controlled and local therapeutic effect on target tissues. Now, a scientific team has pioneered a new breakthrough in the field of photopharmacology with the design of the first wireless device capable of remotely activating a photoactivable drug and causing it to have therapeutic effects on specific organs.
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Brain’s ‘waste disposal network’ is shaped by neural activity, study finds

Over the past decade, intensive studies have shown that the brain’s meningeal lymphatic system acts as the brain’s “waste disposal network,” maintaining homeostasis by clearing metabolic waste and transporting immune cells. However, the mechanism underlying its developmental regulation remains unknown. How does this intricate system form, and which cells or signals govern its specific spatial arrangement in the meninges?
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