Novel breath test shows promise for diagnosing and monitoring bacterial infections
A new, non-invasive breath test has emerged as a potential breakthrough for rapidly diagnosing bacterial infections and tracking treatment effectiveness.
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Investigational gene therapy gives children with rare immune disorder a new lease on life
An investigational gene therapy has successfully restored immune function in all nine children treated with the rare and life-threatening immune disorder called severe leukocyte adhesion deficiency-I, or LAD-I, in an international clinical trial co-led by UCLA.
Semaglutide effectively treats liver disease in two thirds of patients, research finds
Results from the ESSENCE Phase III clinical trial published in the New England Journal of Medicine show treating patients with semaglutide can halt and even reverse liver disease.
Diabetes medication may increase risk of perioperative ketoacidosis
Sodium-glucose cotransporter-2 inhibitors (SGLT2i), or gliflozins, are medications used in the treatment of type 2 diabetes mellitus (T2DM). They are designed to lower high blood glucose levels typical in T2DM, and work by inhibiting the sodium-glucose transport protein 2. SGLT2i have also been shown to improve outcomes among patients with chronic kidney disease, heart failure and coronary artery disease.
Novel rat model could advance COPD-associated cor pulmonale research
Researchers have developed a novel rat model that closely replicates the pathological features and physiological changes associated with human chronic obstructive pulmonary disease (COPD)-associated cor pulmonale. This model exhibits key characteristics, including chronic lung inflammation, pulmonary hypertension, and right ventricular hypertrophy.
Many Medicaid enrollees have restricted access to SGLT2 inhibitors, GLP-1 receptor agonists
Many Medicaid enrollees with type 2 diabetes have restricted access to cardioprotective medications, including sodium-glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs), according to a study published online April 22 in the Annals of Internal Medicine.
Discovery that microglia can be effectively replaced could transform cell therapy for brain diseases
An international research team led by Professor Kiavash Movahedi from the Brussels Center for Immunology at the Vrije Universiteit Brussel has published unexpected results in the journal Immunity. Their study sheds new light on the possibility of effectively replacing defective microglia—the brain’s immune cells—marking a potential breakthrough in the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
Biological age linked to dementia risk in large population study
People whose biological age is higher than their chronological age may be more likely to develop dementia than people whose biological age matches or is lower than their chronological age, according to a study published online in Neurology. Biological age is based on biomarkers of aging such as lung function, blood pressure and cholesterol.
Scientists develop a new model to study hypertension and aortic aneurysms
Oxidative stress can occur when our cells are exposed to harmful molecules called “reactive oxygen species” over time. These reactive oxygen species can damage cells and are found in important disease states, such as high blood pressure and aortic aneurysms. Aortic aneurysms are balloon-like swellings of the body’s largest artery and are often fatal when the aneurysm bursts.
Global shortage of essential nutrient poses health concern
Omega-3 polyunsaturated fatty acids are vital to human health, yet our bodies can’t produce enough of the nutrients naturally—they must be obtained from food or supplements.