Oncology & Cancer

Canadian researchers have developed an effective new technique for identifying aggressive medulloblastoma—the most common type of malignant brain tumor in children—and potentially sparing young patients from unnecessary treatments and their harmful long-term side effects.

Researchers have discovered race-associated molecular differences in tumors that may impact the way patients with pancreatic cancer respond to immunotherapies. The findings, which were recently published in the journal Cancer Research Communications, reinforce the need to include racially diverse participants in clinical studies.

A new PET radiotracer can effectively visualize Nectin-4, an emerging biomarker found in triple-negative breast cancer (TNBC). According to research published in the March issue of The Journal of Nuclear Medicine, the PET tracer has the potential to play a critical role in the diagnosis, treatment, and monitoring of this aggressive disease, improving clinical outcomes for patients.

A research team led by Prof. Sun Cheng from the University of Science and Technology of China (USTC), in collaboration with researchers from the Agency for Science, Technology and Research and Chinese Academy of Agricultural Sciences, has successfully developed a novel spatial immune-based hepatocellular carcinoma (HCC) recurrence risk prediction platform.

Every day, billions of cells in your body divide, helping to replace old and injured cells with new ones. And each time this happens, your entire genetic library—your genome, which totals more than 3 billion base pairs of DNA—has to be copied, precisely, from the parent cell to the new daughter cell.

Researchers at Karolinska Institutet, led by Dr. Helin Norberg and Dr. Erik Norberg, have identified a previously unknown mechanism that affects the ability of cancer cells to spread in the body. The study, published in EMBO Molecular Medicine, shows that a process called chaperone-mediated autophagy (CMA) may function as a natural defense mechanism against metastases.

A new study led by UCLA investigators suggests that chronic stress and an unhealthy diet may work together to fuel the early development of pancreatic cancer, shedding light on how lifestyle factors contribute to one of the deadliest malignancies. The paper is published in the journal Molecular Cancer Research.

For patients with type 2 diabetes (T2D), glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with a reduced risk for developing hematologic cancers compared with insulin and metformin use, according to a research letter published online March 6 in JAMA Network Open.

A University of Rochester Medical Center study showed that downtime in the emergency room can have a potential upside for women who are behind on cervical cancer screenings, which is a nationwide problem.

The Wistar Institute’s Paul M. Lieberman, Ph.D. and lab identified and tested a new method for targeting certain cancers caused by Epstein-Barr Virus (EBV), in the paper, “USP7 inhibitors destabilize EBNA1 and suppress EBV tumorigenesis,” from the Journal of Medical Virology.