Immunofluorescence study sheds light on brain’s DNA damage and repair processes

Brain cells receive sensory inputs from the outside world and send signals throughout the body telling organs and muscles what to do. Although neurons comprise only 10% of brain cells, their functional and genomic integrity must be maintained over a lifetime. Most dividing cells in the body have well-defined checkpoint mechanisms to sense and correct DNA damage during DNA replication.
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Long-read sequencing successfully uncovers genetic causes of rare diseases

The cause of rare diseases is increasingly being detected through genome sequencing, which involves reading the entire human DNA by first breaking it into small pieces—short reads. Christian Gilissen, Lisenka Vissers, and colleagues found that a new technique using long reads is even more effective at detecting complex causes. They report that 80–90% of cases were detectable, as stated in The American Journal of Human Genetics.
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Study finds that community health workers were vital to Orange County’s COVID-19 response

Community health workers were found to be the unsung heroes of the health care system’s pandemic response, according to a study led by a team of public health researchers from the University of California, Irvine, and their community partners. Findings also show that current funding and reimbursement mechanisms remain inadequate to sustain their work.
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ADHD diagnoses in adults surged post-2020, while teen rates stabilized

New research identifies differing trends in attention-deficit/hyperactivity disorder (ADHD) diagnoses among adolescents and adults, including an increase among adults from 2020 to 2023. The study, published in the journal Psychiatric Research and Clinical Practice, found a significant downward trends in ADHD incidence among adults from 2016 to 2020 and adolescents from 2016 to 2018. The ADHD incidence rate remained stable for adolescents in subsequent years.
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