Drug reshapes tissue architecture to reduce damage in alcohol-related liver disease

Researchers from the Roger Williams Institute of Liver Studies at King’s College London developed two 3D models from human tissue to understand the effects that a drug—a cyclophilin inhibitor—has on liver tissue damaged by alcohol. They found that the drug stops the build-up of proteins responsible for making the tissue stiff—a characteristic of liver disease—allowing the liver to remodel itself back to a healthier state.
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First mechanism for cognitive disorders in schizophrenia found

Schizophrenia is a debilitating mental disorder affecting around 1% of the population worldwide, and is notoriously difficult to treat. Current medications for schizophrenia can ameliorate positive symptoms, such as hallucinations and delusions. However, there is still a huge unmet medical need for treating negative symptoms, including social withdrawal and lack of motivation, and cognitive symptoms, including impaired attention and memory function.
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