Macrophages elicit separate pathways for inflammation and lysosomal function in diseases due to toxic particle exposure

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium urate crystals, or MSUc; CPPD disease, another inflammatory joint disease driven by calcium pyrophosphate dihydrate crystals, or CPPDc; and the lung disease silicosis, driven by inhaled silica-derived nanoparticles.
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Dual-targeting radiopharmaceutical therapy safe and effective across multiple cancers

A new cancer treatment that delivers radiation directly to tumors by targeting two key markers simultaneously has been shown to be safe and effective in human trials. Acting like a “smart missile,” the dual-targeting radiopharmaceutical is designed to attach to two vulnerable sites on cancer cells, enabling more precise and potent therapy. Early results show that nearly 90% of patients experienced either tumor shrinkage or disease stabilization. These findings were presented at the Society of Nuclear Medicine and Molecular Imaging 2025 Annual Meeting.
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PET imaging links brain inflammation to speech disorder and Parkinson-like syndrome

A novel PET imaging approach has revealed distinct patterns of brain inflammation in patients with progressive apraxia of speech (PAOS), a rare neurodegenerative disorder that affects speech planning. These findings provide new insight into how neuroinflammation and tau pathology may drive disease progression in PAOS, opening potential avenues for earlier diagnosis and targeted treatments.
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