T cells take up residence in the healthy brain via a gut-fat-brain axis

The brain is a unique place. It is shielded from much of the body by the blood-brain barrier, meaning it’s protected from pathogens and potentially dangerous substances that might be in our blood. And historically, many scientists believed that separation extended to the immune system as well: the brain has its own specialized immune cells called microglia, but immune cells present in the rest of the body were long thought to steer clear of the brain unless there was a disease or other problem requiring their presence.
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An overlooked cell type orchestrates brain rewiring during states of heightened attention

Researchers at Washington University School of Medicine in St. Louis have upended the decades-old dogma of how connections between brain cells are rearranged during states of heightened vigilance or attention. The team found that a brain chemical associated with alertness, attention and learning alters brain connectivity and function not by acting directly on neurons, the cells known for their quick transmission of information, but through the work of astrocytes, another, slower-acting type of brain cell that is often overlooked in the field of neuroscience.
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